Anti-Phospho-Cyclin E1-Thr77 antibody [R02-6U7] (STJA0036119)

Name: Anti-Phospho-Cyclin E1-Thr77 antibody [R02-6U7] (STJA0036119)
SKU: STJA0036119
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenA synthesized peptide derived from human Cyclin E1

STJA0036119

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Short Description	Rabbit monoclonal anti-Phospho-Cyclin E1-Thr77 for use in WB, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ICC/IF
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	R02-6U7
Isotype	IgG
Conjugation	Unconjugated
Purification	Affinity Chromatography
Dilution Range	WB 1:500-1:1000 IHC 1:50-1:100 IF 1:50-1:200
Formulation	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction	Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.

Gene Symbol	CCNE1
Gene ID	898
Uniprot ID	CCNE1_HUMAN
Immunogen	A synthesized peptide derived from human Cyclin E1

Tissue Specificity	Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Post Translational Modifications	Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. Ubiquitinated by UHRF2.appears to occur independently of phosphorylation.
Function	Essential for the control of the cell cycle at the G1/S (start) transition.
Protein Name	G1/S-Specific Cyclin-E1
Database Links	Reactome: R-HSA-1538133 Reactome: R-HSA-187577 Reactome: R-HSA-2559586 Reactome: R-HSA-390471 Reactome: R-HSA-6804116 Reactome: R-HSA-69017 Reactome: R-HSA-69200 Reactome: R-HSA-69202 Reactome: R-HSA-69205 Reactome: R-HSA-69231 Reactome: R-HSA-69563 Reactome: R-HSA-8849470 Reactome: R-HSA-9661069 Reactome: R-HSA-9706019
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-G1/S-Specific Cyclin-E1 antibody Anti-CCNE1 antibody Anti-CCNE antibody

Information sourced from Uniprot.org