Anti-Phospho-CSF2RB-Tyr593 antibody (559-608 aa) (STJ90799)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human IL-3R beta around the phosphorylation site of Tyr593 at the amino acid range 559-608
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Cytokine receptor common subunit beta-Tyr593 (559-608 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CSF2RB |
| Gene ID | 1439 |
| Uniprot ID | IL3RB_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human IL-3R beta around the phosphorylation site of Tyr593 at the amino acid range 559-608 |
| Immunogen Region | 559-608 aa |
| Specificity | Phospho-IL-3R Beta (Y593) Polyclonal Antibody detects endogenous levels of IL-3R Beta protein only when phosphorylated at Y593. |
Additional Info
| Function | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Cytokine Receptor Common Subunit BetaCdw131Gm-Csf/Il-3/Il-5 Receptor Common Beta SubunitCd Antigen Cd131 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-5683826Reactome: R-HSA-5688849Reactome: R-HSA-5688890Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cytokine Receptor Common Subunit Beta antibodyAnti-Cdw131 antibodyAnti-Gm-Csf/Il-3/Il-5 Receptor Common Beta Subunit antibodyAnti-Cd Antigen Cd131 antibodyAnti-CSF2RB antibodyAnti-IL3RB antibodyAnti-IL5RB antibody |
Information sourced from Uniprot.org