Anti-Phospho-CDX2-Ser283 antibody (STJA0009981)

SKU:
STJA0009981

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Homeobox protein CDX-2-Ser283 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDX2
Gene ID: 1045
Uniprot ID: CDX2_HUMAN
Specificity: This antibody detects endogenous levels of CDX2 (Phospho-Ser283) at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human CDX2 (Phospho-Ser283)
Tissue Specificity Detected in small intestine, colon and pancreas.
Post Translational Modifications Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
Function Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.
Protein Name Homeobox Protein Cdx-2
Cdx-3
Caudal-Type Homeobox Protein 2
Database Links Reactome: R-HSA-381771
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Homeobox Protein Cdx-2 antibody
Anti-Cdx-3 antibody
Anti-Caudal-Type Homeobox Protein 2 antibody
Anti-CDX2 antibody
Anti-CDX3 antibody

Information sourced from Uniprot.org

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