• Western blot analysis of lysates from LOVO cells, using Calcium Sensing Receptor (Phospho-Thr888) Antibody. The lane on the right is blocked with the phospho peptide.
  • Immunofluorescence analysis of HeLa cells, using Calcium Sensing Receptor (Phospho-Thr888) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-CASR-Thr888 antibody (854-903 aa) (STJ90701)

SKU:
STJ90701

Current Stock:
Host: Rabbit
Applications: WB/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Extracellular calcium-sensing receptor-Thr888 (854-903 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CASR
Gene ID: 846
Uniprot ID: CASR_HUMAN
Immunogen Region: 854-903 aa
Specificity: Phospho-CaSR (T888) Polyclonal Antibody detects endogenous levels of CaSR protein only when phosphorylated at T888.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Calcium Sensing Receptor around the phosphorylation site of Thr888 at the amino acid range 854-903
Post Translational Modifications N-glycosylated. Ubiquitinated by RNF19A.which induces proteasomal degradation.
Function G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation.
Protein Name Extracellular Calcium-Sensing Receptor
Car
Casr
Hcasr
Parathyroid Cell Calcium-Sensing Receptor 1
Pcar1
Database Links Reactome: R-HSA-416476
Reactome: R-HSA-418594
Reactome: R-HSA-420499
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Extracellular Calcium-Sensing Receptor antibody
Anti-Car antibody
Anti-Casr antibody
Anti-Hcasr antibody
Anti-Parathyroid Cell Calcium-Sensing Receptor 1 antibody
Anti-Pcar1 antibody
Anti-CASR antibody
Anti-GPRC2A antibody
Anti-PCAR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance