Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Phospho-Fanconi anemia group J protein-Thr1133 is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:1000-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | BRIP1 |
Gene ID: | 83990 |
Uniprot ID: | FANCJ_HUMAN |
Specificity: | This antibody detects endogenous levels of Human BACH1 or BRIP1 (phospho-Thr1133) |
Immunogen: | Synthesized phosho peptide around human BACH1 and BRIP1 (Thr1133) |
Post Translational Modifications | Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle regulated. Acetylation at Lys-1249 facilitates DNA end processing required for repair and checkpoint signaling. |
Function | DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. |
Protein Name | Fanconi Anemia Group J ProteinProtein FacjAtp-Dependent Rna Helicase Brip1Brca1-Associated C-Terminal Helicase 1Brca1-Interacting Protein C-Terminal Helicase 1Brca1-Interacting Protein 1 |
Database Links | Reactome: R-HSA-2564830Reactome: R-HSA-5685938Reactome: R-HSA-5685942Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579Reactome: R-HSA-5693607Reactome: R-HSA-5693616Reactome: R-HSA-6804756Reactome: R-HSA-69473Reactome: R-HSA-9701192Reactome: R-HSA-9704331Reactome: R-HSA-9704646Reactome: R-HSA-9709570Reactome: R-HSA-9709603 |
Cellular Localisation | NucleusCytoplasm |
Alternative Antibody Names | Anti-Fanconi Anemia Group J Protein antibodyAnti-Protein Facj antibodyAnti-Atp-Dependent Rna Helicase Brip1 antibodyAnti-Brca1-Associated C-Terminal Helicase 1 antibodyAnti-Brca1-Interacting Protein C-Terminal Helicase 1 antibodyAnti-Brca1-Interacting Protein 1 antibodyAnti-BRIP1 antibodyAnti-BACH1 antibodyAnti-FANCJ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance