Anti-Phospho-BCAR1-Tyr-762 antibody (STJA0005509)

SKU:
STJA0005509-100

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-p130 Cas-Tyr-762 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:2000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Bcar1
Gene ID: 25414
Uniprot ID: BCAR1_RAT
Specificity: This antibody was cross-adsorbed to phospho-tyrosine coupled to agarose and to phospho-p130 Cas (Tyr-751) peptide before affinity purification using phospho-p130 Cas (Tyr-762) peptide (without carrier). The antibody detects a 130 kDa* protein corresp
Immunogen: Phospho-p130 Cas (Tyr-762) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 762 in the Src-binding domain of rat p130 Cas. This rat sequence is the same as Tyr-664 in human p130 Cas and Tyr-668 in mouse p130 Cas
Post Translational Modifications PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif.phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix. Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner.phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway. Dephosphorylated by PTPN14 at Tyr-226.
Function Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration and cell branching. Involved in the BCAR3-mediated inhibition of TGFB signaling.
Protein Name Breast Cancer Anti-Estrogen Resistance Protein 1
Crk-Associated Substrate
P130cas
Database Links Reactome: R-RNO-186763
Reactome: -RNO-372708
Reactome: -RNO-4420097
Reactome: -RNO-8849471
Cellular Localisation Cell Junction
Focal Adhesion
Cytoplasm
Cell Projection
Axon
Unphosphorylated Form Localizes In The Cytoplasm
Localizes To Focal Adhesion Sites Following Integrin Engagement
Alternative Antibody Names Anti-Breast Cancer Anti-Estrogen Resistance Protein 1 antibody
Anti-Crk-Associated Substrate antibody
Anti-P130cas antibody
Anti-Bcar1 antibody
Anti-Cas antibody
Anti-Crkas antibody

Information sourced from Uniprot.org

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