| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-BAG family molecular chaperone regulator 3-Tyr457 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BAG3 |
| Gene ID: |
9531 |
| Uniprot ID: |
BAG3_HUMAN |
| Specificity: |
This antibody detects endogenous levels of BAG3 (Phospho-Tyr457) at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human BAG3 (Phospho-Tyr457) |
| Function | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport. |
| Protein Name | Bag Family Molecular Chaperone Regulator 3Bag-3Bcl-2-Associated Athanogene 3Bcl-2-Binding Protein BisDocking Protein Cair-1 |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Hsf1 To The Nucleus Upon Heat Stress |
| Alternative Antibody Names | Anti-Bag Family Molecular Chaperone Regulator 3 antibodyAnti-Bag-3 antibodyAnti-Bcl-2-Associated Athanogene 3 antibodyAnti-Bcl-2-Binding Protein Bis antibodyAnti-Docking Protein Cair-1 antibodyAnti-BAG3 antibodyAnti-BIS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
