Anti-PHLDA3/TIH1 antibody (C-Term) (STJ70467)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PHLDA3/TIH1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB-Trf |
| Host | Goat |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: In transfected HEK293 transiently expressing full-length Human PHLDA3 (myc and DYKDDDDK tagged) , a band of approx. 18kDa was observed. No bands were observed in mock-transfected HEK29 |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PHLDA3 |
| Gene ID | 23612 |
| Uniprot ID | PHLA3_HUMAN |
| Accession Number | NP_036528.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | RARQSLGTGTLVS |
Additional Info
| Function | p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. |
| Protein Name | Pleckstrin Homology-Like Domain Family A Member 3Tdag51/Ipl Homolog 1 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Pleckstrin Homology-Like Domain Family A Member 3 antibodyAnti-Tdag51/Ipl Homolog 1 antibodyAnti-PHLDA3 antibodyAnti-TIH1 antibody |
Information sourced from Uniprot.org