| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PHF21A (461-680) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PHF21A |
| Gene ID: |
51317 |
| Uniprot ID: |
PF21A_HUMAN |
| Immunogen Region: |
461-680 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 461-680 of human PHF21A (NP_001095272.1). |
| Immunogen Sequence: |
TETTFTFPAPVQPVSLPSPT STDGDIHEDFCSVCRKSGQL LMCDTCSRVYHLDCLDPPLK TIPKGMWICPRCQDQMLKKE EAIPWPGTLAIVHSYIAYKA AKEEEKQKLLKWSSDLKQER EQLEQKVKQLSNSISKCMEM KNTILARQKEMHSSLEKVKQ LIRLIHGIDLSKPVDSEATV GAISNGPDCTPPANAATSTP APSPSSQSCTANCNQGEETK |
| Tissue Specificity | Highly expressed in brain. Expressed at lower level in other tissues, including heart, kidney, liver, lung and skeletal muscle. Abundantly expressed in fetal brain. |
| Function | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. |
| Protein Name | Phd Finger Protein 21aBhc80aBraf35-Hdac Complex Protein Bhc80 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-9679191Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Phd Finger Protein 21a antibodyAnti-Bhc80a antibodyAnti-Braf35-Hdac Complex Protein Bhc80 antibodyAnti-PHF21A antibodyAnti-BHC80 antibodyAnti-KIAA1696 antibodyAnti-BM-006 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
