Anti-PHF21A antibody (461-680) (STJ28252)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PHF21A (461-680) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PHF21A |
| Gene ID | 51317 |
| Uniprot ID | PF21A_HUMAN |
| Immunogen Region | 461-680 |
| Immunogen Sequence | TETTFTFPAPVQPVSLPSPT STDGDIHEDFCSVCRKSGQL LMCDTCSRVYHLDCLDPPLK TIPKGMWICPRCQDQMLKKE EAIPWPGTLAIVHSYIAYKA AKEEEKQKLLKWSSDLKQER EQLEQKVKQLSNSISKCMEM KNTILARQKEMHSSLEKVKQ LIRLIHGIDLSKPVDSEATV GAISNGPDCTPPANAATSTP APSPSSQSCTANCNQGEETK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 461-680 of human PHF21A (NP_001095272.1). |
Additional Info
| Tissue Specificity | Highly expressed in brain. Expressed at lower level in other tissues, including heart, kidney, liver, lung and skeletal muscle. Abundantly expressed in fetal brain. |
| Function | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. |
| Protein Name | Phd Finger Protein 21aBhc80aBraf35-Hdac Complex Protein Bhc80 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-9679191Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Phd Finger Protein 21a antibodyAnti-Bhc80a antibodyAnti-Braf35-Hdac Complex Protein Bhc80 antibodyAnti-PHF21A antibodyAnti-BHC80 antibodyAnti-KIAA1696 antibodyAnti-BM-006 antibody |
Information sourced from Uniprot.org