Anti-PGC1 beta antibody (924-1023) [S1MR] (STJ11103561)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal PGC1 beta (924-1023) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPARGC1B |
| Gene ID | 133522 |
| Uniprot ID | PRGC2_HUMAN |
| Immunogen Region | 924-1023 |
| Immunogen Sequence | VFGEIEECEVLTRNRRGEKY GFITYRCSEHAALSLTKGAA LRKRNEPSFQLSYGGLRHFC WPRYTDYDSNSEEALPASGK SKYEAMDFDSLLKEAQQSLH |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 924-1023 of human PGC1 beta (NP_573570.3). |
Additional Info
| Tissue Specificity | Ubiquitous with higher expression in heart, brain and skeletal muscle. |
| Function | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. |
| Protein Name | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-BetaPgc-1-BetaPpar-Gamma Coactivator 1-BetaPpargc-1-BetaPgc-1-Related Estrogen Receptor Alpha Coactivator |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-8939902Reactome: R-HSA-9841922Reactome: R-HSA-9844594 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta antibodyAnti-Pgc-1-Beta antibodyAnti-Ppar-Gamma Coactivator 1-Beta antibodyAnti-Ppargc-1-Beta antibodyAnti-Pgc-1-Related Estrogen Receptor Alpha Coactivator antibodyAnti-PPARGC1B antibodyAnti-PERC antibodyAnti-PGC1 antibodyAnti-PGC1B antibodyAnti-PPARGC1 antibody |
Information sourced from Uniprot.org