Anti-PGAP6 antibody (647-697 aa) (STJ193802)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TMM8A at the amino acid range 647-697
General Information
| Short Description | Rabbit polyclonal anti-Post-GPI attachment to proteins factor 6 (647-697 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PGAP6 |
| Gene ID | 58986 |
| Uniprot ID | PGAP6_HUMAN |
| Immunogen | Synthesized peptide derived from the human TMM8A at the amino acid range 647-697 |
| Immunogen Region | 647-697 aa |
| Specificity | This antibody detects endogenous levels of TMM8A at Human/Mouse |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane. In contrast to myomaker (TMEM8C), has no fusogenic activity. |
| Protein Name | Post-Gpi Attachment To Proteins Factor 6Gpi Processing Phospholipase A2Gpi-Pla2Protein M83Transmembrane Protein 6Transmembrane Protein 8Transmembrane Protein 8a |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-Post-Gpi Attachment To Proteins Factor 6 antibodyAnti-Gpi Processing Phospholipase A2 antibodyAnti-Gpi-Pla2 antibodyAnti-Protein M83 antibodyAnti-Transmembrane Protein 6 antibodyAnti-Transmembrane Protein 8 antibodyAnti-Transmembrane Protein 8a antibodyAnti-PGAP6 antibodyAnti-TMEM6 antibodyAnti-TMEM8 antibodyAnti-TMEM8A antibody |
Information sourced from Uniprot.org