| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Post-GPI attachment to proteins factor 6 (647-697 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PGAP6 |
| Gene ID: |
58986 |
| Uniprot ID: |
PGAP6_HUMAN |
| Immunogen Region: |
647-697 aa |
| Specificity: |
This antibody detects endogenous levels of TMM8A at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human TMM8A at the amino acid range 647-697 |
| Post Translational Modifications | Glycosylated. |
| Function | Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane. In contrast to myomaker (TMEM8C), has no fusogenic activity. |
| Protein Name | Post-Gpi Attachment To Proteins Factor 6Gpi Processing Phospholipase A2Gpi-Pla2Protein M83Transmembrane Protein 6Transmembrane Protein 8Transmembrane Protein 8a |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-Post-Gpi Attachment To Proteins Factor 6 antibodyAnti-Gpi Processing Phospholipase A2 antibodyAnti-Gpi-Pla2 antibodyAnti-Protein M83 antibodyAnti-Transmembrane Protein 6 antibodyAnti-Transmembrane Protein 8 antibodyAnti-Transmembrane Protein 8a antibodyAnti-PGAP6 antibodyAnti-TMEM6 antibodyAnti-TMEM8 antibodyAnti-TMEM8A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
