| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Profilin-2 (1-140) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PFN2 |
| Gene ID: |
5217 |
| Uniprot ID: |
PROF2_HUMAN |
| Immunogen Region: |
1-140 |
| Immunogen: |
Recombinant Protein corresponding to a sequence within amino acids 1-140 of human PFN2 (NP_444252.1). |
| Immunogen Sequence: |
MAGWQSYVDNLMCDGCCQEA AIVGYCDAKYVWAATAGGVF QSITPIEIDMIVGKDREGFF TNGLTLGAKKCSVIRDSLYV DGDCTMDIRTKSQGGEPTYN VAVGRAGRVLVFVMGKEGVH GGGLNKKAYSMAKYLRDSGF |
| Tissue Specificity | Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. |
| Function | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. |
| Protein Name | Profilin-2Profilin Ii |
| Database Links | Reactome: R-HSA-376176Reactome: R-HSA-5663220 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Profilin-2 antibodyAnti-Profilin Ii antibodyAnti-PFN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
