Anti-PFN1 antibody (1-140) (STJ24964)

Name: Anti-PFN1 antibody (1-140) (STJ24964)
SKU: STJ24964
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ24964

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Short Description	Rabbit polyclonal PFN1 (1-140) antibody for use in WB and ELISA in human, mouse, rat and monkey samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat/Monkey
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	PFN1
Gene ID	5216
Uniprot ID	PROF1_HUMAN
Immunogen Region	1-140
Immunogen Sequence	MAGWNAYIDNLMADGTCQDA AIVGYKDSPSVWAAVPGKTF VNITPAEVGVLVGKDRSSFY VNGLTLGGQKCSVIRDSLLQ DGEFSMDLRTKSTGGAPTFN VTVTKTDKTLVLLMGKEGVH GGLINKKCYEMASHLRRSQY
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human Profilin1 (NP_005013.1).

Tissue Specificity	Expressed in epididymis (at protein level).
Post Translational Modifications	Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.
Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Protein Name	Profilin-1 Epididymis Tissue Protein Li 184a Profilin I
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-376176 Reactome: R-HSA-4086400 Reactome: R-HSA-5663220
Cellular Localisation	Cytoplasm Cytoskeleton
Alternative Antibody Names	Anti-Profilin-1 antibody Anti-Epididymis Tissue Protein Li 184a antibody Anti-Profilin I antibody Anti-PFN1 antibody

Information sourced from Uniprot.org