Anti-PEX6 antibody (C-Term) (STJ72262)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PEX6 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Pig/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 100kDa band observed in Rat Liver lysates (calculated MW of 104kDa according to Rat NP_476466.1). Recommended concentration: 0.3-1µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PEX6 |
| Gene ID | 5190 |
| Uniprot ID | PEX6_HUMAN |
| Accession Number | NP_000278.3 |
| Immunogen Region | C-Term |
| Immunogen Sequence | EQELLRYKRIQRK |
Additional Info
| Function | Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5. |
| Protein Name | Peroxisomal Atpase Pex6Peroxin-6Peroxisomal Biogenesis Factor 6Peroxisomal-Type Atpase 1Peroxisome Assembly Factor 2Paf-2 |
| Database Links | Reactome: R-HSA-9033241 |
| Cellular Localisation | CytoplasmCytosolPeroxisome MembraneCell ProjectionCiliumPhotoreceptor Outer SegmentAssociated With Peroxisomal MembranesAnchored By Pex26 To Peroxisome MembranesLocalized At The Base Of The Outer Segment Of Photoreceptor Cells |
| Alternative Antibody Names | Anti-Peroxisomal Atpase Pex6 antibodyAnti-Peroxin-6 antibodyAnti-Peroxisomal Biogenesis Factor 6 antibodyAnti-Peroxisomal-Type Atpase 1 antibodyAnti-Peroxisome Assembly Factor 2 antibodyAnti-Paf-2 antibodyAnti-PEX6 antibodyAnti-PXAAA1 antibody |
Information sourced from Uniprot.org