Anti-PEX6 antibody (480-560 aa) (STJ191142)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 480-560
General Information
| Short Description | Rabbit polyclonal anti-Peroxisomal ATPase PEX6 (480-560 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PEX6 |
| Gene ID | 5190 |
| Uniprot ID | PEX6_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 480-560 |
| Immunogen Region | 480-560 aa |
| Specificity | PEX6 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5. |
| Protein Name | Peroxisomal Atpase Pex6Peroxin-6Peroxisomal Biogenesis Factor 6Peroxisomal-Type Atpase 1Peroxisome Assembly Factor 2Paf-2 |
| Database Links | Reactome: R-HSA-9033241 |
| Cellular Localisation | CytoplasmCytosolPeroxisome MembraneCell ProjectionCiliumPhotoreceptor Outer SegmentAssociated With Peroxisomal MembranesAnchored By Pex26 To Peroxisome MembranesLocalized At The Base Of The Outer Segment Of Photoreceptor Cells |
| Alternative Antibody Names | Anti-Peroxisomal Atpase Pex6 antibodyAnti-Peroxin-6 antibodyAnti-Peroxisomal Biogenesis Factor 6 antibodyAnti-Peroxisomal-Type Atpase 1 antibodyAnti-Peroxisome Assembly Factor 2 antibodyAnti-Paf-2 antibodyAnti-PEX6 antibodyAnti-PXAAA1 antibody |
Information sourced from Uniprot.org