Anti-PEX2 antibody (1-50 aa) (STJ95040)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PXMP3 at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-Peroxisome biogenesis factor 2 (1-50 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PEX2 |
| Gene ID | 5828 |
| Uniprot ID | PEX2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PXMP3 at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | Peroxin 2 Polyclonal Antibody detects endogenous levels of Peroxin 2 protein. |
Additional Info
| Function | E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12.each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase. PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol. Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70. Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis. |
| Protein Name | Peroxisome Biogenesis Factor 235 Kda Peroxisomal Membrane ProteinPeroxin-2Peroxisomal Membrane Protein 3Peroxisome Assembly Factor 1Paf-1Ring Finger Protein 72 |
| Database Links | Reactome: R-HSA-8866654Reactome: R-HSA-9033241Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Peroxisome Biogenesis Factor 2 antibodyAnti-35 Kda Peroxisomal Membrane Protein antibodyAnti-Peroxin-2 antibodyAnti-Peroxisomal Membrane Protein 3 antibodyAnti-Peroxisome Assembly Factor 1 antibodyAnti-Paf-1 antibodyAnti-Ring Finger Protein 72 antibodyAnti-PEX2 antibodyAnti-PAF1 antibodyAnti-PMP3 antibodyAnti-PMP35 antibodyAnti-PXMP3 antibodyAnti-RNF72 antibody |
Information sourced from Uniprot.org