Anti-PERM1 antibody (434-484 aa) (STJ195593)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CA170 at the amino acid range 434-484
General Information
| Short Description | Rabbit polyclonal anti-PGC-1 and ERR-induced regulator in muscle protein 1 (434-484 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PERM1 |
| Gene ID | 84808 |
| Uniprot ID | PERM1_HUMAN |
| Immunogen | Synthesized peptide derived from the human CA170 at the amino acid range 434-484 |
| Immunogen Region | 434-484 aa |
| Specificity | This antibody detects endogenous levels of CA170 at Human/Mouse |
Additional Info
| Function | Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. |
| Protein Name | Pgc-1 And Err-Induced Regulator In Muscle Protein 1Ppargc1 And Esrr-Induced Regulator In Muscle 1Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 And Estrogen-Related Receptor-Induced Regulator In Muscle 1 |
| Database Links | Reactome: R-HSA-2151201 |
| Cellular Localisation | CytoplasmNucleusShows A Nuclear Localization In The Presence Of Ppargc1a |
| Alternative Antibody Names | Anti-Pgc-1 And Err-Induced Regulator In Muscle Protein 1 antibodyAnti-Ppargc1 And Esrr-Induced Regulator In Muscle 1 antibodyAnti-Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 And Estrogen-Related Receptor-Induced Regulator In Muscle 1 antibodyAnti-PERM1 antibodyAnti-C1orf170 antibody |
Information sourced from Uniprot.org