| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PGC-1 and ERR-induced regulator in muscle protein 1 (434-484 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PERM1 |
| Gene ID: |
84808 |
| Uniprot ID: |
PERM1_HUMAN |
| Immunogen Region: |
434-484 aa |
| Specificity: |
This antibody detects endogenous levels of CA170 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human CA170 at the amino acid range 434-484 |
| Function | Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. |
| Protein Name | Pgc-1 And Err-Induced Regulator In Muscle Protein 1Ppargc1 And Esrr-Induced Regulator In Muscle 1Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 And Estrogen-Related Receptor-Induced Regulator In Muscle 1 |
| Database Links | Reactome: R-HSA-2151201 |
| Cellular Localisation | CytoplasmNucleusShows A Nuclear Localization In The Presence Of Ppargc1a |
| Alternative Antibody Names | Anti-Pgc-1 And Err-Induced Regulator In Muscle Protein 1 antibodyAnti-Ppargc1 And Esrr-Induced Regulator In Muscle 1 antibodyAnti-Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 And Estrogen-Related Receptor-Induced Regulator In Muscle 1 antibodyAnti-PERM1 antibodyAnti-C1orf170 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
