Anti-Periostin antibody (STJA0038035)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Periostin
General Information
| Short Description | Rabbit monoclonal anti-Periostin for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | IHC 1:100-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | POSTN |
| Gene ID | 10631 |
| Uniprot ID | POSTN_HUMAN |
| Immunogen | A synthesized peptide derived from human Periostin |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Expressed in the kidney. Expressed in the lung. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers. |
| Post Translational Modifications | Gamma-carboxylation is controversial. Gamma-carboxyglutamated.gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation.this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues. |
| Function | Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX. |
| Protein Name | PeriostinPnOsteoblast-Specific Factor 2Osf-2 |
| Database Links | |
| Cellular Localisation | Golgi ApparatusSecretedExtracellular SpaceExtracellular MatrixColocalizes With Bmp1 In The Golgi |
| Alternative Antibody Names | Anti-Periostin antibodyAnti-Pn antibodyAnti-Osteoblast-Specific Factor 2 antibodyAnti-Osf-2 antibodyAnti-POSTN antibodyAnti-OSF2 antibody |
Information sourced from Uniprot.org