Anti-Perilipin 1 antibody (100-150 aa) (STJ13100237)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 100-150 of human Perilipin 1 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-Perilipin 1 (100-150 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | PLIN1 |
| Gene ID | 5346 |
| Uniprot ID | PLIN1_HUMAN |
| Immunogen | A synthetic peptide from aa region 100-150 of human Perilipin 1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 100-150 aa |
| Specificity | Specific for Perilipin 1. |
Additional Info
| Post Translational Modifications | Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet. |
| Function | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. |
| Protein Name | Perilipin-1Lipid Droplet-Associated Protein |
| Database Links | Reactome: R-HSA-163560Reactome: R-HSA-381340Reactome: R-HSA-9031528Reactome: R-HSA-9841922 |
| Cellular Localisation | Endoplasmic ReticulumLipid DropletLipid Droplet Surface-Associated |
| Alternative Antibody Names | Anti-Perilipin-1 antibodyAnti-Lipid Droplet-Associated Protein antibodyAnti-PLIN1 antibodyAnti-PERI antibodyAnti-PLIN antibody |
Information sourced from Uniprot.org