| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PEG3 |
| Gene ID: | 5178 |
| Uniprot ID: | PEG3_HUMAN |
| Immunogen Region: | 195-400 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 195-400 of human PEG3 (NP_006201.1). |
| Immunogen Sequence: | LSLPVVAKTSFEMDREDDRD SRAYESRSQDAESYQNVVDL AEDRKPHNTIQDNMENYRKL LSLVQLAEDDGHSHMTQGHS SRSKRSAYPSTSRGLKTMPE AKKSTHRRGICEDESSHGVI MEKFIKDVSRSSKSGRARES SDRSQRFPRMSDDNWKDISL NKRESVIQQRVYEGNAFRGG FRFNSTLVSRKRVLERKRRY HFDTDG |
| Tissue Specificity | Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines. |
| Function | Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells. |
| Protein Name | Paternally-Expressed Gene 3 ProteinZinc Finger And Scan Domain-Containing Protein 24 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Paternally-Expressed Gene 3 Protein antibodyAnti-Zinc Finger And Scan Domain-Containing Protein 24 antibodyAnti-PEG3 antibodyAnti-KIAA0287 antibodyAnti-ZSCAN24 antibody |
Information sourced from Uniprot.org