| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Na+/H+ exchange regulatory cofactor NHE-RF3/H+ exchanger regulatory factor 3 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDZK1 |
| Gene ID: |
5174 |
| Uniprot ID: |
NHRF3_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PDZK1 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human PDZK1 |
| Function | A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. |
| Protein Name | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf3Nherf-3Cftr-Associated Protein Of 70 KdaNa(+/H(+ Exchanger Regulatory Factor 3Na/Pi Cotransporter C-Terminal-Associated Protein 1Napi-Cap1Pdz Domain-Containing Protein 1Sodium-Hydrogen Exchanger Regulatory Factor 3 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCell MembraneAssociated With Peripheral MembranesLocalizes To The Apical Compartment Of Proximal Tubular Cells And To Sinusoidal Liver Membranes |
| Alternative Antibody Names | Anti-Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf3 antibodyAnti-Nherf-3 antibodyAnti-Cftr-Associated Protein Of 70 Kda antibodyAnti-Na(+/H(+ Exchanger Regulatory Factor 3 antibodyAnti-Na/Pi Cotransporter C-Terminal-Associated Protein 1 antibodyAnti-Napi-Cap1 antibodyAnti-Pdz Domain-Containing Protein 1 antibodyAnti-Sodium-Hydrogen Exchanger Regulatory Factor 3 antibodyAnti-PDZK1 antibodyAnti-CAP70 antibodyAnti-NHERF3 antibodyAnti-PDZD1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
