Anti-PDXP antibody (STJA0009232)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PDXP
General Information
| Short Description | Rabbit polyclonal anti-Chronophin for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDXP |
| Gene ID | 57026 |
| Uniprot ID | PLPP_HUMAN |
| Immunogen | Synthesized peptide derived from human PDXP |
| Specificity | This antibody detects endogenous levels of PDXP at Human, Mouse, Rat |
Additional Info
| Function | Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine. |
| Protein Name | ChronophinPyridoxal Phosphate PhosphatasePlp Phosphatase |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolCytoskeletonCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideLamellipodium MembraneCell MembraneColocalizes With The Actin Cytoskeleton In Membrane Ruffles And LamellipodiaDiffusely Distributed Throughout The Cytosol During Pro-Metaphase And MetaphaseDetected At The Dynamic Cell Poles During TelophaseDetected At The Cleavage Furrow And Contractile Ring During CytokinesisTransiently Detected At The Plasma Membrane In Late Stages Of CytokinesisDetected At The Midbody |
| Alternative Antibody Names | Anti-Chronophin antibodyAnti-Pyridoxal Phosphate Phosphatase antibodyAnti-Plp Phosphatase antibodyAnti-PDXP antibodyAnti-CIN antibodyAnti-PLP antibodyAnti-PLPP antibody |
Information sourced from Uniprot.org