Anti-PDXP antibody (C-Term) (STJ72421)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PDXP (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 32kDa band observed in Human and Rat Heart lysates and in Mouse and Rat Brain lysates (calculated MW of 31.7kDa according to NP_064711.1). Recommended concentration: 0.1-0.3ยตg/m |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PDXP |
| Gene ID | 57026 |
| Uniprot ID | PLPP_HUMAN |
| Accession Number | NP_064711.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | QHDLVPHYYVES |
Additional Info
| Function | Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine. |
| Protein Name | ChronophinPyridoxal Phosphate PhosphatasePlp Phosphatase |
| Cellular Localisation | CytoplasmCytosolCytoskeletonCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideLamellipodium MembraneCell MembraneColocalizes With The Actin Cytoskeleton In Membrane Ruffles And LamellipodiaDiffusely Distributed Throughout The Cytosol During Pro-Metaphase And MetaphaseDetected At The Dynamic Cell Poles During TelophaseDetected At The Cleavage Furrow And Contractile Ring During CytokinesisTransiently Detected At The Plasma Membrane In Late Stages Of CytokinesisDetected At The Midbody |
| Alternative Antibody Names | Anti-Chronophin antibodyAnti-Pyridoxal Phosphate Phosphatase antibodyAnti-Plp Phosphatase antibodyAnti-PDXP antibodyAnti-CIN antibodyAnti-PLP antibodyAnti-PLPP antibody |
Information sourced from Uniprot.org