• Western blot analysis of various lysates using PDLIM5 Rabbit polyclonal antibody (STJ28287) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Anti-PDLIM5 antibody (317-596) (STJ28287)

SKU:
STJ28287

£169.50 - £449.50
Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PDLIM5 (317-596) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PDLIM5
Gene ID: 10611
Uniprot ID: PDLI5_HUMAN
Immunogen Region: 317-596
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 317-596 of human PDLIM5 (NP_006448.4).
Immunogen Sequence: ASSVASTRSMPESLDSPTSG RPGVTSLTTAAAFKPVGSTG VIKSPSWQRPNQGVPSTGRI SNSATYSGSVAPANSALGQT QPSDQDTLVQRAEHIPAGKR TPMCAHCNQVIRGPFLVALG KSWHPEEFNCAHCKNTMAYI GFVEEKGALYCELCYEKFFA PECGRCQRKILGEVISALKQ TWHVSCFVCVACGKPIRNNV FHLEDGEPYCETDYYALFGT ICHGCEFPIEAGDMFLEAL
Tissue Specificity Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
Function May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation.
Protein Name Pdz And Lim Domain Protein 5
Enigma Homolog
Enigma-Like Pdz And Lim Domains Protein
Database Links Reactome: R-HSA-6794361
Cellular Localisation Postsynaptic Density
Presynapse
Postsynapse
Cytoplasm
Cytosol
Detected Both At Presynaptic And Postsynaptic Sites
Exclusively At Excitatory Synapses
But Not Inhibitory Synapses
In Hippocampal Neurons
Alternative Antibody Names Anti-Pdz And Lim Domain Protein 5 antibody
Anti-Enigma Homolog antibody
Anti-Enigma-Like Pdz And Lim Domains Protein antibody
Anti-PDLIM5 antibody
Anti-ENH antibody
Anti-L9 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance