Anti-PDLIM5 antibody (208-257 aa) (STJ95012)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PDLIM5 at the amino acid range 208-257
General Information
| Short Description | Rabbit polyclonal anti-PDZ and LIM domain protein 5 (208-257 aa) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDLIM5 |
| Gene ID | 10611 |
| Uniprot ID | PDLI5_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PDLIM5 at the amino acid range 208-257 |
| Immunogen Region | 208-257 aa |
| Specificity | PDLIM5 Polyclonal Antibody detects endogenous levels of PDLIM5 protein. |
Additional Info
| Function | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. |
| Protein Name | Pdz And Lim Domain Protein 5Enigma HomologEnigma-Like Pdz And Lim Domains Protein |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Postsynaptic DensityPresynapsePostsynapseCytoplasmCytosolDetected Both At Presynaptic And Postsynaptic SitesExclusively At Excitatory SynapsesBut Not Inhibitory SynapsesIn Hippocampal Neurons |
| Alternative Antibody Names | Anti-Pdz And Lim Domain Protein 5 antibodyAnti-Enigma Homolog antibodyAnti-Enigma-Like Pdz And Lim Domains Protein antibodyAnti-PDLIM5 antibodyAnti-ENH antibodyAnti-L9 antibody |
Information sourced from Uniprot.org