• Confocal imaging of HeLa cells using PDIA6 Rabbit monoclonal antibody (STJ11102028, dilution 1:100) (Green). The cells were counterstained with Alpha-tubulin (ubiquitous) chain Rabbit monoclonal antibody (dilution 1:100) (Red). DAPI was used for nuclear staining (blue). Objective: 60x.
  • Western blot analysis of extracts of Mouse liver, using PDIA6 Rabbit monoclonal antibody (STJ11102028) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 3min.
  • Western blot analysis of extracts of various cell lines, using PDIA6 Rabbit monoclonal antibody (STJ11102028) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.

Anti-PDIA6 antibody (1-100) [S8MR] (STJ11102028)

SKU:
STJ11102028

£212.50 - £501.50
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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-PDIA6 (1-100) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S8MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PDIA6
Gene ID: 10130
Uniprot ID: PDIA6_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PDIA6 (NP_005733.1).
Immunogen Sequence: MALLVLGLVSCTFFLAVNGL YSSSDDVIELTPSNFNREVI QSDSLWLVEFYAPWCGHCQR LTPEWKKAATALKDVVKVGA VDADKHHSLGGQYGVQGFPT
Tissue Specificity Expressed in platelets (at protein level).
Function May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
Protein Name Protein Disulfide-Isomerase A6
Endoplasmic Reticulum Protein 5
Er Protein 5
Erp5
Protein Disulfide Isomerase P5
Thioredoxin Domain-Containing Protein 7
Database Links Reactome: R-HSA-381038
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation Endoplasmic Reticulum Lumen
Cell Membrane
Melanosome
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Alternative Antibody Names Anti-Protein Disulfide-Isomerase A6 antibody
Anti-Endoplasmic Reticulum Protein 5 antibody
Anti-Er Protein 5 antibody
Anti-Erp5 antibody
Anti-Protein Disulfide Isomerase P5 antibody
Anti-Thioredoxin Domain-Containing Protein 7 antibody
Anti-PDIA6 antibody
Anti-ERP5 antibody
Anti-P5 antibody
Anti-TXNDC7 antibody

Information sourced from Uniprot.org

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