Anti-PDGFD antibody (311-360 aa) (STJ96664)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human PDGFD at the amino acid range 311-360
General Information
| Short Description | Rabbit polyclonal anti-Platelet-derived growth factor D (311-360 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDGFD |
| Gene ID | 80310 |
| Uniprot ID | PDGFD_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human PDGFD at the amino acid range 311-360 |
| Immunogen Region | 311-360 aa |
| Specificity | PDGF-D Polyclonal Antibody detects endogenous levels of PDGF-D protein. |
Additional Info
| Post Translational Modifications | Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form. |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. |
| Protein Name | Platelet-Derived Growth Factor DPdgf-DIris-Expressed Growth FactorSpinal Cord-Derived Growth Factor BScdgf-B Cleaved Into - Platelet-Derived Growth Factor D - Latent FormPdgfd Latent Form - Platelet-Derived Growth Factor D - Receptor-Binding FormPdgfd Receptor-Binding Form |
| Database Links | Reactome: R-HSA-186797 |
| Cellular Localisation | SecretedReleased By Platelets Upon Wounding |
| Alternative Antibody Names | Anti-Platelet-Derived Growth Factor D antibodyAnti-Pdgf-D antibodyAnti-Iris-Expressed Growth Factor antibodyAnti-Spinal Cord-Derived Growth Factor B antibodyAnti-Scdgf-B Cleaved Into - Platelet-Derived Growth Factor D - Latent Form antibodyAnti-Pdgfd Latent Form - Platelet-Derived Growth Factor D - Receptor-Binding Form antibodyAnti-Pdgfd Receptor-Binding Form antibodyAnti-PDGFD antibodyAnti-IEGF antibodyAnti-SCDGFB antibodyAnti-MSTP036 antibodyAnti-UNQ1899 antibodyAnti-PRO4345 antibody |
Information sourced from Uniprot.org