Anti-PDE9A antibody {Biotin} (STJ502390)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenSynthetic cyclic peptide common to all PDE9A variants
General Information
| Short Description | Rabbit polyclonal antibody anti-PDE9A is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | CM/ELISA/ICC/IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.55 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:100ELISA: 1:100IP: 1:250IHC: 1:100ICC: 1:100IF: 1:100CFM: 1:100 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE9A |
| Gene ID | 5152 |
| Uniprot ID | PDE9A_HUMAN |
| Immunogen | Synthetic cyclic peptide common to all PDE9A variants |
| Specificity | Does not cross-react with PDE9B protein or any other PDE family members. |
Additional Info
| Tissue Specificity | Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate. In brain, present in the cortex, cerebellum, and subiculum (at protein level). In heart, primarily localizes to myocytes. |
| Function | Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory. |
| Protein Name | High Affinity Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase 9a |
| Database Links | Reactome: R-HSA-418457 |
| Cellular Localisation | Isoform Pde9a1: Cell ProjectionRuffle MembraneCytoplasmPerinuclear RegionGolgi ApparatusEndoplasmic ReticulumCell MembraneSarcolemmaIsoform Pde9a2: Cell ProjectionIsoform Pde9a3: CytoplasmIsoform Pde9a17: Cytoplasm |
| Alternative Antibody Names | Anti-High Affinity Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase 9a antibodyAnti-PDE9A antibody |
Information sourced from Uniprot.org