| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PDE8A (1-120) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDE8A |
| Gene ID: |
5151 |
| Uniprot ID: |
PDE8A_HUMAN |
| Immunogen Region: |
1-120 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human PDE8A (NP_002596.1). |
| Immunogen Sequence: |
MGCAPSIHISERLVAEDAPS PAAPPLSSGGPRLPQGQKTA ALPRTRGAGLLESELRDGSG KKVAVADVQFGPMRFHQDQL QVLLVFTKEDNQCNGFCRAC EKAGFKCTVTKEAQAVLACF |
| Tissue Specificity | Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon. |
| Post Translational Modifications | Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine. |
| Protein Name | High Affinity Camp-Specific And Ibmx-Insensitive 3' -5'-Cyclic Phosphodiesterase 8a |
| Database Links | Reactome: R-HSA-418555 |
| Alternative Antibody Names | Anti-High Affinity Camp-Specific And Ibmx-Insensitive 3' -5'-Cyclic Phosphodiesterase 8a antibodyAnti-PDE8A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
