Anti-PDE5A antibody (120-170) (STJ502349)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide common to all PDE5A variants taken within amino acid region 120-170 on human PDE5A protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-PDE5A (120-170) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | CM/ELISA/ICC/IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Chicken/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.55-0.60 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500-1:1, 000DB: 1:10, 000ELISA: 1:10, 000IP: 1:250IHC: 1:250ICC: 1:250IF: 1:250CFM: 1:250 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE5A |
| Gene ID | 8654 |
| Uniprot ID | PDE5A_HUMAN |
| Immunogen | Synthetic peptide common to all PDE5A variants taken within amino acid region 120-170 on human PDE5A protein. |
| Immunogen Region | 120-170 |
| Specificity | Does not cross-react with other PDE family members. |
Additional Info
| Tissue Specificity | Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. |
| Post Translational Modifications | Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation. |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. |
| Protein Name | Cgmp-Specific 3' -5'-Cyclic PhosphodiesteraseCgmp-Binding Cgmp-Specific PhosphodiesteraseCgb-Pde |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-445355Reactome: R-HSA-9013422 |
| Alternative Antibody Names | Anti-Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase antibodyAnti-Cgmp-Binding Cgmp-Specific Phosphodiesterase antibodyAnti-Cgb-Pde antibodyAnti-PDE5A antibodyAnti-PDE5 antibody |
Information sourced from Uniprot.org