Anti-PDE5A antibody (120-170) {Biotin} (STJ502351)

SKU:
STJ502351-100

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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Chicken/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PDE5A (120-170) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.60 µg/µl
Dilution Range: WB: 1:500-1:1, 000
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:250
IHC: 1:250
ICC: 1:250
IF: 1:250
CFM: 1:250
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE5A
Gene ID: 8654
Uniprot ID: PDE5A_HUMAN
Immunogen Region: 120-170
Specificity: Does not cross-react with other PDE family members.
Immunogen: Synthetic peptide common to all PDE5A variants taken within amino acid region 120-170 on human PDE5A protein.
Tissue Specificity Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
Post Translational Modifications Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation.
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
Protein Name Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase
Cgmp-Binding Cgmp-Specific Phosphodiesterase
Cgb-Pde
Database Links Reactome: R-HSA-418457
Reactome: R-HSA-445355
Reactome: R-HSA-9013422
Alternative Antibody Names Anti-Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase antibody
Anti-Cgmp-Binding Cgmp-Specific Phosphodiesterase antibody
Anti-Cgb-Pde antibody
Anti-PDE5A antibody
Anti-PDE5 antibody

Information sourced from Uniprot.org

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