Anti-PDE4A1 antibody {FITC} (STJ502283)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide specific for PDE4A1 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-PDE4A1 is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | CM/ELISA/ICC/IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.57 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:250IHC: 1:250ICC: 1:250IF: 1:250CFM: 1:250 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Pde4a |
| Gene ID | 25638 |
| Uniprot ID | PDE4A_RAT |
| Immunogen | Synthetic peptide specific for PDE4A1 protein. |
Additional Info
| Tissue Specificity | Isoform 2: Isoform 2 is testis specific. |
| Post Translational Modifications | Isoform 1: Phosphorylated by MAPKAPK2 at Ser-147.it counteracts PKA-induced activation of PDE4A and modulates intracellular cAMP levels. Likely involved in cellular desensitization to cAMP signaling. Proteolytically cleaved by CASP3. |
| Function | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Isoform 1: Efficiently hydrolyzes cAMP. Isoform 2: Efficiently hydrolyzes cAMP. |
| Protein Name | 3' -5'-Cyclic-Amp Phosphodiesterase 4aDpde2Camp-Specific Phosphodiesterase 4a |
| Database Links | Reactome: R-RNO-180024Reactome: -RNO-418555 |
| Cellular Localisation | Isoform 2: CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-3' -5'-Cyclic-Amp Phosphodiesterase 4a antibodyAnti-Dpde2 antibodyAnti-Camp-Specific Phosphodiesterase 4a antibodyAnti-Pde4a antibody |
Information sourced from Uniprot.org