| Host: |
Rabbit |
| Applications: |
CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PDE4A1 is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.57 µg/µl |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:250IHC: 1:250ICC: 1:250IF: 1:250CFM: 1:250 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Pde4a |
| Gene ID: |
25638 |
| Uniprot ID: |
PDE4A_RAT |
| Immunogen: |
Synthetic peptide specific for PDE4A1 protein. |
| Tissue Specificity | Isoform 2: Isoform 2 is testis specific. |
| Post Translational Modifications | Isoform 1: Phosphorylated by MAPKAPK2 at Ser-147.it counteracts PKA-induced activation of PDE4A and modulates intracellular cAMP levels. Likely involved in cellular desensitization to cAMP signaling. Proteolytically cleaved by CASP3. |
| Function | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Isoform 1: Efficiently hydrolyzes cAMP. Isoform 2: Efficiently hydrolyzes cAMP. |
| Protein Name | Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4aDpde2 |
| Database Links | Reactome: R-RNO-180024Reactome: -RNO-418555 |
| Cellular Localisation | Isoform 2: CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4a antibodyAnti-Dpde2 antibodyAnti-Pde4a antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
