Anti-PDE3A antibody {FITC} (STJ502267)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide selective only for PDE3A variants
General Information
| Short Description | Goat polyclonal antibody anti-PDE3A is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Goat |
| Reactivity | Human/Monkey/Mouse/Rat/Xenopus |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.72 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:250ICC: 1:250IF: 1:250CFM: 1:250 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE3A |
| Gene ID | 5139 |
| Uniprot ID | PDE3A_HUMAN |
| Immunogen | Synthetic peptide selective only for PDE3A variants |
Additional Info
| Function | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. |
| Protein Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3aCyclic Gmp-Inhibited Phosphodiesterase ACgi-Pde ACgmp-Inhibited Camp PhosphodiesteraseCgi-Pde |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmCytosol |
| Alternative Antibody Names | Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a antibodyAnti-Cyclic Gmp-Inhibited Phosphodiesterase A antibodyAnti-Cgi-Pde A antibodyAnti-Cgmp-Inhibited Camp Phosphodiesterase antibodyAnti-Cgi-Pde antibodyAnti-PDE3A antibody |
Information sourced from Uniprot.org