• Western blot with Anti-PDE1C Antibody (STJ502238) with PD1C peptide. Antibody at 1:500 dilution in buffer.

Anti-PDE1C antibody (1-50) (STJ502238)

SKU:
STJ502238-100

£481.50
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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PDE1C (1-50) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500-1:2, 000
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:40-1:100
ICC: 1:40-1:100
IF: 1:100
CFM: 1:40-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE1C
Gene ID: 5137
Uniprot ID: PDE1C_HUMAN
Immunogen Region: 1-50
Specificity: Does not cross-react with PDE1A, PDE1B, or other PDE family members. This antibody will label all PDE1C variants including PDE1C1, PDE1C2, and PDE1C3.
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene.
Tissue Specificity Isoform PDE1C2 is present in the heart and brain and, at lower levels in the lung, liver, kidney and skeletal muscle. Isoform PDE1C1 is expressed in the heart and brain and, at lower levels in lung. Also expressed at low levels in uterus and testis.
Function Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
Protein Name Dual Specificity Calcium/Calmodulin-Dependent 3' -5'-Cyclic Nucleotide Phosphodiesterase 1c
Cam-Pde 1c
Hcam3
Database Links Reactome: R-HSA-111957
Cellular Localisation Lysosome
Alternative Antibody Names Anti-Dual Specificity Calcium/Calmodulin-Dependent 3' -5'-Cyclic Nucleotide Phosphodiesterase 1c antibody
Anti-Cam-Pde 1c antibody
Anti-Hcam3 antibody
Anti-PDE1C antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance