Anti-PDE11A antibody (100-150) {Biotin} (STJ502210)

Name: Anti-PDE11A antibody (100-150) {Biotin} (STJ502210)
SKU: STJ502210-100
Price: 686.55 USD
Availability: InStock

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SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationBiotin

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acid region 100-150 on PDE11A protein, common to all PDE11A variants.

STJ502210-100

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Short Description	Rabbit polyclonal antibody anti-PDE11A (100-150) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Applications	CM/ELISA/ICC/IF/IHC/IP/WB
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Biotin
Concentration	0.68 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:250 IHC: 1:250 ICC: 1:250 IF: 1:250 CFM: 1:250
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	PDE11A
Gene ID	50940
Uniprot ID	PDE11_HUMAN
Immunogen	Synthetic peptide taken within amino acid region 100-150 on PDE11A protein, common to all PDE11A variants.
Immunogen Region	100-150
Specificity	Does not cross-react with any of the members of the PDE family. This antibody is common to all PDE11A variants including PDE11A1-PDE11A4.

Tissue Specificity	Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
Function	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Protein Name	Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11a Camp And Cgmp Phosphodiesterase 11a
Database Links	Reactome: R-HSA-418457 Reactome: R-HSA-418555
Cellular Localisation	Cytoplasm Cytosol
Alternative Antibody Names	Anti-Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11a antibody Anti-Camp And Cgmp Phosphodiesterase 11a antibody Anti-PDE11A antibody

Information sourced from Uniprot.org