• Immunohistochemistry with Anti-PDE10A Antibody (STJ502199) at 1:100 dilution in Buffer. DAB (brown) staining and Haematoxylin QS (blue) counterstain. 40X magnification. FFPE section.

Anti-PDE10A antibody (250-325) (STJ502199)

SKU:
STJ502199-100

£481.50
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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PDE10A (250-325) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.7 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100-1:150
ICC: 1:100-1:150
IF: 1:100-1:150
CFM: 1:100-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE10A
Gene ID: 10846
Uniprot ID: PDE10_HUMAN
Immunogen Region: 250-325
Specificity: This antibody has no cross-reactivity against any other PDE family members tested so far. This antibody will detect all PDE10A variants and subtypes.
Immunogen: Synthetic peptide (Human) taken against a common sequence near the 250-325 amino acids downstream of N-terminal region of PDE10A. Synthetic MAP.
Tissue Specificity Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Post Translational Modifications Isoform PDE10A2: Phosphorylated on Thr-16.
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Protein Name Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a
Database Links Reactome: R-HSA-418457
Reactome: R-HSA-418555
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a antibody
Anti-PDE10A antibody

Information sourced from Uniprot.org

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