Anti-PDCD4 antibody (1-469aa) [4C2] (STJA0041974)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human PDCD4 (1-469aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-PDCD4 (1-469aa) for use in ELISA, WB, ICC, IF and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF/FACS |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 4C2 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDCD4 |
| Gene ID | 27250 |
| Uniprot ID | PDCD4_HUMAN |
| Accession Number | NP_055271 |
| Immunogen | Recombinant human PDCD4 (1-469aa) purified from E. coli |
| Immunogen Region | 1-469aa |
Additional Info
| Tissue Specificity | Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. |
| Post Translational Modifications | Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation. Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens.phosphorylation promotes proteasomal degradation of PDCD4. |
| Function | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA. |
| Protein Name | Programmed Cell Death Protein 4Neoplastic Transformation Inhibitor ProteinNuclear Antigen H731-LikeProtein 197/15a |
| Database Links | Reactome: R-HSA-8950505 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And CytoplasmPredominantly Nuclear Under Normal Growth ConditionsAnd When Phosphorylated At Ser-457 |
| Alternative Antibody Names | Anti-Programmed Cell Death Protein 4 antibodyAnti-Neoplastic Transformation Inhibitor Protein antibodyAnti-Nuclear Antigen H731-Like antibodyAnti-Protein 197/15a antibodyAnti-PDCD4 antibodyAnti-H731 antibody |
Information sourced from Uniprot.org