Anti-PCYT1A antibody (1-100) (STJ11102806)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PCYT1A (1-100) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PCYT1A |
| Gene ID | 5130 |
| Uniprot ID | PCY1A_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MDAQCSAKVNARKRRKEAPG PNGATEEDGVPSKVQRCAVG LRQPAPFSDEIEVDFSKPYV RVTMEEASRGTPCERPVRVY ADGIFDLFHSGHARALMQAK |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PCYT1A (NP_001299602.1). |
Additional Info
| Tissue Specificity | Brain, placenta, liver, fetal and adult lung. |
| Post Translational Modifications | The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation. Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. |
| Function | Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. |
| Protein Name | Choline-Phosphate Cytidylyltransferase ACct-AlphaCtp -Phosphocholine Cytidylyltransferase ACct ACt APhosphorylcholine Transferase A |
| Database Links | Reactome: R-HSA-1483191 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneNucleusIt Can Interconvert Between An Inactive Cytosolic Form And An Active Membrane-Bound Form |
| Alternative Antibody Names | Anti-Choline-Phosphate Cytidylyltransferase A antibodyAnti-Cct-Alpha antibodyAnti-Ctp -Phosphocholine Cytidylyltransferase A antibodyAnti-Cct A antibodyAnti-Ct A antibodyAnti-Phosphorylcholine Transferase A antibodyAnti-PCYT1A antibodyAnti-CTPCT antibodyAnti-PCYT1 antibody |
Information sourced from Uniprot.org