Anti-PCSK4 antibody (STJA0008634)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PCSK4
General Information
| Short Description | Rabbit polyclonal anti-Proprotein convertase subtilisin/kexin type 4 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PCSK4 |
| Gene ID | 54760 |
| Uniprot ID | PCSK4_HUMAN |
| Immunogen | Synthesized peptide derived from human PCSK4 |
| Specificity | This antibody detects endogenous levels of PCSK4 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | N-glycosylated. Synthesized in the endoplasmic reticulum as a zymogen, is matured by autocatalytic cleavage between the prodomain and the catalytic domain. |
| Function | Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida. Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2. May also participate in folliculogenesis in the ovaries. |
| Protein Name | Proprotein Convertase Subtilisin/Kexin Type 4Proprotein Convertase 4Pc4 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinCytoplasmic VesicleSecretory VesicleAcrosome Membrane |
| Alternative Antibody Names | Anti-Proprotein Convertase Subtilisin/Kexin Type 4 antibodyAnti-Proprotein Convertase 4 antibodyAnti-Pc4 antibodyAnti-PCSK4 antibodyAnti-PC4 antibodyAnti-UNQ2757 antibodyAnti-PRO6496 antibody |
Information sourced from Uniprot.org