Anti-PCGF6 antibody [R04-7J6] (STJA0034692)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of mouse PCGF6
General Information
| Short Description | Rabbit monoclonal anti-PCGF6 for use in WB, ICC, IF and IP in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-7J6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Pcgf6 |
| Gene ID | 71041 |
| Uniprot ID | PCGF6_MOUSE |
| Immunogen | Recombinant protein of mouse PCGF6 |
Additional Info
| Tissue Specificity | Expressed in ovary, testis, stomach, liver, thymus and kidney (at protein level). |
| Post Translational Modifications | Phosphorylated during mitosis. |
| Function | Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. |
| Protein Name | Polycomb Group Ring Finger Protein 6Mel18 And Bmi1-Like Ring FingerRing Finger Protein 134 |
| Database Links | Reactome: R-MMU-8953750 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polycomb Group Ring Finger Protein 6 antibodyAnti-Mel18 And Bmi1-Like Ring Finger antibodyAnti-Ring Finger Protein 134 antibodyAnti-Pcgf6 antibodyAnti-Mblr antibodyAnti-Rnf134 antibody |
Information sourced from Uniprot.org