| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PCGF6 (161-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PCGF6 |
| Gene ID: |
84108 |
| Uniprot ID: |
PCGF6_HUMAN |
| Immunogen Region: |
161-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 161-350 of human PCGF6 (NP_001011663.1). |
| Immunogen Sequence: |
RHFYYSNRCPKCNIVVHQTQ PLYNIRLDRQLQDIVYKLVI NLEEREKKQMHDFYKERGLE VPKPAVPQPVPSSKGRSKKV LESVFRIPPELDMSLLLEFI GANEGTGHFKPLEKKFVRVS GEATIGHVEKFLRRKMGLDP ACQVDIICGDHLLEQYQTLR EIRRAIGDAAMQDGLLVLHY GLVVSPLKIT |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro. |
| Function | Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. |
| Protein Name | Polycomb Group Ring Finger Protein 6Mel18 And Bmi1-Like Ring FingerRing Finger Protein 134 |
| Database Links | Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polycomb Group Ring Finger Protein 6 antibodyAnti-Mel18 And Bmi1-Like Ring Finger antibodyAnti-Ring Finger Protein 134 antibodyAnti-PCGF6 antibodyAnti-MBLR antibodyAnti-RNF134 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
