Anti-PCGF2 antibody (STJ193132)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Polycomb group RING finger protein 2 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PCGF2 |
| Gene ID | 7703 |
| Uniprot ID | PCGF2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | PCGF2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated. Homodimer formation is regulated by phosphorylation with only unphosphorylated proteins forming homodimers. |
| Function | Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. |
| Protein Name | Polycomb Group Ring Finger Protein 2Dna-Binding Protein Mel-18Ring Finger Protein 110Zinc Finger Protein 144 |
| Database Links | Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-5617472Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polycomb Group Ring Finger Protein 2 antibodyAnti-Dna-Binding Protein Mel-18 antibodyAnti-Ring Finger Protein 110 antibodyAnti-Zinc Finger Protein 144 antibodyAnti-PCGF2 antibodyAnti-MEL18 antibodyAnti-RNF110 antibodyAnti-ZNF144 antibody |
Information sourced from Uniprot.org