| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PCGF1 (160-259) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PCGF1 |
| Gene ID: |
84759 |
| Uniprot ID: |
PCGF1_HUMAN |
| Immunogen Region: |
160-259 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-259 of human PCGF1 (NP_116062.2). |
| Immunogen Sequence: |
AHYYRYDEQLNLCLERLSSG KDKNKSVLQNKYVRCSVRAE VRHLRRVLCHRLMLNPQHVQ LLFDNEVLPDHMTMKQIWLS RWFGKPSPLLLQYSVKEKRR |
| Tissue Specificity | Ubiquitous. |
| Function | Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6.this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells. |
| Protein Name | Polycomb Group Ring Finger Protein 1Nervous System Polycomb-1Nspc1Ring Finger Protein 68 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polycomb Group Ring Finger Protein 1 antibodyAnti-Nervous System Polycomb-1 antibodyAnti-Nspc1 antibodyAnti-Ring Finger Protein 68 antibodyAnti-PCGF1 antibodyAnti-NSPC1 antibodyAnti-RNF68 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
