Anti-PBK antibody (1-322) (STJ11104418)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Lymphokine-Activated Killer T-Cell-Originated Protein Kinase (1-322) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PBK |
| Gene ID | 55872 |
| Uniprot ID | TOPK_HUMAN |
| Immunogen Region | 1-322 |
| Immunogen Sequence | MEGISNFKTPSKLSEKKKSV LCSTPTINIPASPFMQKLGF GTGVNVYLMKRSPRGLSHSP WAVKKINPICNDHYRSVYQK RLMDEAKILKSLHHPNIVGY RAFTEANDGSLCLAMEYGGE KSLNDLIEERYKASQDPFPA AIILKVALNMARGLKYLHQE KKLLHGDIKSSNVVIKGDFE TIKICDVGVSLPLDENMTVT DPEACYIGTEPWKPKEAVEE NGVITDKADIFAFGLTLWE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human PBK (NP_060962.2). |
Additional Info
| Tissue Specificity | Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. |
| Post Translational Modifications | Phosphorylated.in a cell-cycle dependent manner at mitosis. |
| Function | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. |
| Protein Name | Lymphokine-Activated Killer T-Cell-Originated Protein KinaseCancer/Testis Antigen 84Ct84Mapkk-Like Protein KinaseNori-3Pdz-Binding KinaseSpermatogenesis-Related Protein KinaseSpkT-Lak Cell-Originated Protein Kinase |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Lymphokine-Activated Killer T-Cell-Originated Protein Kinase antibodyAnti-Cancer/Testis Antigen 84 antibodyAnti-Ct84 antibodyAnti-Mapkk-Like Protein Kinase antibodyAnti-Nori-3 antibodyAnti-Pdz-Binding Kinase antibodyAnti-Spermatogenesis-Related Protein Kinase antibodyAnti-Spk antibodyAnti-T-Lak Cell-Originated Protein Kinase antibodyAnti-PBK antibodyAnti-TOPK antibody |
Information sourced from Uniprot.org