Anti-PAX6 antibody [1C8] (STJ98310)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of human Pax-6 expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Paired box protein Pax-6 for use in WB, FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 1C8 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000FC 1:200-1:400ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAX6 |
| Gene ID | 5080 |
| Uniprot ID | PAX6_HUMAN |
| Immunogen | Purified recombinant fragment of human Pax-6 expressed in E. Coli. |
| Specificity | Pax-6 Monoclonal Antibody detects endogenous levels of Pax-6 protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression. |
| Protein Name | Paired Box Protein Pax-6Aniridia Type Ii ProteinOculorhombin |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-381771Reactome: R-HSA-400511Reactome: R-HSA-5617472Reactome: R-HSA-9823739 |
| Cellular Localisation | NucleusIsoform 1: NucleusIsoform 5a: Nucleus |
| Alternative Antibody Names | Anti-Paired Box Protein Pax-6 antibodyAnti-Aniridia Type Ii Protein antibodyAnti-Oculorhombin antibodyAnti-PAX6 antibodyAnti-AN2 antibody |
Information sourced from Uniprot.org