Anti-PAX5 antibody (120-170) (STJ502156)

SKU:
STJ502156-100

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Host: Rabbit
Applications: ELISA/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PAX5 (120-170) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.65-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PAX5
Gene ID: 5079
Uniprot ID: PAX5_HUMAN
Immunogen Region: 120-170
Immunogen: Synthetic peptide taken within amino acid region 120-170 on human PAX5 protein.
Post Translational Modifications O-glycosylated. Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation.
Function Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire. (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription. Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity.
Protein Name Paired Box Protein Pax-5
B-Cell-Specific Transcription Factor
Bsap
Database Links Reactome: R-HSA-8939245
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Paired Box Protein Pax-5 antibody
Anti-B-Cell-Specific Transcription Factor antibody
Anti-Bsap antibody
Anti-PAX5 antibody

Information sourced from Uniprot.org

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