| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAWR (200-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAWR |
| Gene ID: |
5074 |
| Uniprot ID: |
PAWR_HUMAN |
| Immunogen Region: |
200-300 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PAR4 (NP_002574.2) |
| Immunogen Sequence: |
QNEAVNLLDPGSSYLLQEPP RTVSGRYKSTTSVSEEDVSS RYSRTDRSGFPRYNRDANVS GTLVSSSTLEKKIEDLEKEV VRERQENLRLVRLMQDKEEM I |
| Tissue Specificity | Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. |
| Post Translational Modifications | Preferentially phosphorylated at the Thr-163 by PKC in cancer cells. |
| Function | Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. |
| Protein Name | Prkc Apoptosis Wt1 Regulator ProteinProstate Apoptosis Response 4 ProteinPar-4 |
| Cellular Localisation | CytoplasmNucleusMainly Cytoplasmic In Absence Of Apoptosis Signal And In Normal CellsNuclear In Most Cancer Cell LinesNuclear Entry Seems To Be Essential But Not Sufficient For ApoptosisNuclear Localization Includes Nucleoplasm And Pml Nuclear Bodies |
| Alternative Antibody Names | Anti-Prkc Apoptosis Wt1 Regulator Protein antibodyAnti-Prostate Apoptosis Response 4 Protein antibodyAnti-Par-4 antibodyAnti-PAWR antibodyAnti-PAR4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
